Double Room
- 1 King-size bed
- Shower
- Heating
- Air conditioning
Hotel · Rome · Lazio
Twentyone Hotel
A modern 4-star hotel steps from the Vatican, with clean, soundproofed rooms and a dedicated team that draws consistent praise for service.
- Location rating 9 – within easy reach of the Vatican, shopping streets and a metro stop
- Soundproofed, air-conditioned rooms with modern design and flat-screen TVs
- Helpful staff, 24-hour reception and paid airport shuttle available
8.4
Great
5869 reviews
Booking.com 8.4 · 5869 reviews
About
Twentyone Hotel
Twentyone Hotel occupies a handy position in Rome’s Prati district, about a 20-minute walk from Campo de’ Fiori and even closer to the Vatican. The 4-star property combines minimalist interiors with practical touches: soundproofed rooms, a fitness centre, and a bar/lounge area. Guests have access to a barber shop, luggage storage, and laundry services.
The hotel offers seven room types, from Double and Twin to Family and Deluxe categories with balconies. Each room includes air conditioning, heating, a mini-bar, and tea/coffee-making facilities. Security features (key-card access, smoke detectors) and a 24-hour reception add convenience. Parking is available on site, and an electric vehicle charging station is also provided.
- Non-smoking rooms
- Wi-Fi
- Parking
- Safe deposit box
- 24-hour reception
- Express check-in/ -out
In brief
What works, what to weigh
+
Strengths
3 reasons to book- Prime location near the Vatican and shopping — rated 9/10 by guests, with multiple reviewers noting easy access to the Vatican, a metro station, and a shopping street lined with good stores.
- Friendly, attentive staff — from helping with currency exchange to arranging online check-in for flights, the team is regularly called out for going above and beyond.
- Good value for a 4-star in Rome — with rates starting at £70 and many guests commenting that the service and cleanliness justify the price for the class.
–
Worth weighing
3 to weigh- Some rooms feel tight on space — a few guests mention the layout can be awkward, especially when moving between the wardrobe and bathroom, and the size is average for Rome rather than generous.
- Breakfast costs extra and is not cheap — in-room breakfast runs about €10 per person, which some guests find pricey compared to nearby cafés where you can get a better meal with a view.
- Limited check-in window — check-in is only between 15:00 and 23:59, which may be inconvenient for early arrivals. Pets are not allowed, and parking (while available) is not described as free.
01 — Rooms
Rooms & rates
High season: summer dates usually book out a few weeks ahead.
Twin Room
- 2 Single beds
- Shower
- Heating
- Air conditioning
Triple Room
- 3 Single beds
- Shower
- Heating
- Air conditioning
Family Room
- 2 Single beds
- Shower
- Heating
- Bathtub
- Air conditioning
Deluxe Twin Room
- 2 Single beds
- Shower
- Heating
- Balcony
- Air conditioning
Superior Double Room
- 1 King-size bed
- Shower
- Heating
- Bathtub
- Air conditioning
Deluxe Double Room
- 1 King-size bed
- Shower
- Heating
- Balcony
- Air conditioning
02 — Amenities
Services & amenities
Everything included at this stay — the facilities and essentials, at a glance.
General Services
- 24-hour reception
- Express check-in/ -out
- Room service
- Housekeeping
- Laundry
- Dry cleaning
- Tours/Ticket assistance
- Welcome drink
- Paid airport shuttle
Room Amenities
- Air conditioning
- Heating
- Mini-bar
- Soundproofed rooms
- Sitting area
- Terrace
- Garden furniture
- Tea and coffee facilities
- Ironing facilities
- Free toiletries
- Flat-screen TV
- AM/FM alarm clock
Food & Drink
- Restaurant
- Snack bar
- Bar/ Lounge area
- In-room breakfast
- Packed lunches
- Special diet menus
- Children's buffet
Accessibility
- Rooms/ Facilities for disabled
- Wheelchair access
- Toilet for disabled
- Bathroom for disabled
Business & Leisure
- Fitness centre
- Leisure/ TV room
- Fax/Photocopying
- Barber shop
Security & Comfort
- Safe deposit box
- Security
- Smoke detectors
- Fire extinguishers
- Key card access
- Allergy-free rooms
- Lift
- Non-smoking rooms
Photos
Gallery
03 — Reviews
What guests say
Recent verified reviews from guests who stayed here.
Guest-rated 8.4/10 from 5,869 reviews
Booking.com · 8.4 · 5869 reviews
8.4Verified guest“Excellent spot with fast Wi-Fi, round-the-clock reception, and a pleasant bar. On my first stay, the staff pointed me to a currency exchange, which was a big help. I strongly recommend it – I'm already booked for another business trip.”
8.4Verified guest“Really enjoyed this top-quality hotel – easy to find, with attentive reception staff. The location right by a metro station couldn't have been better, and there were plenty of shops and a shopping street nearby.”
8.4Verified guest“This was our third hotel in Italy. The design is very distinctive, the place is spotless (as far as the eye can see – I didn't bring a UV light to check the sheets), and the room was nice, though a little tight moving from the cupboard to the bathroom. Breakfast was lovely, but we tried having it in bed and it cost about €10 each – a bit steep; you can get a much better deal at a café with a view for that price. Our room looked onto a courtyard – nothing special, but it got plenty of sun. The staff were extremely helpful.”
8.4Verified guest“The breakfasts were the best – perfect pastries and cheese, among other things.”
8.4Verified guest“Fantastic location, very friendly staff, and the rooms were extremely clean and comfortable.”
8.4Verified guest“Our room was clean, modern, and reasonably priced. The decor was high standard and the shower was excellent. It served as a great base for exploring Rome. We were anxious about checking in online for our return flights, but we were able to do it at the hotel – the staff were very helpful.”
04 — Location
Getting around Rome
The property sits in Rome.
Vatican City: The hotel is within a short walk of St. Peter’s Basilica and the Vatican Museums, making it a convenient choice for sightseers.
Shopping & Dining: Via Cola di Rienzo is a major shopping street with many stores and cafés. Campo de’ Fiori market is about a 20-minute walk away.
Transport: A metro station is just steps from the hotel, providing quick connections to the historic centre and Termini Station.
Via Cola Di Rienzo 23, Rome, Lazio, 00192, Italy
05 — Good to know
Policies & conditions
Hotel details are shown for reference. Final rate terms are confirmed on the partner’s site at booking.
- Check-in
- From 15:00-23:59
- Check-out
- By 07:00-11:00
- Cancellation
- Free cancellation on many rates — terms on booking page
- Payment
- Pay-at-hotel available on many rates; final terms at booking
- Pets
- Not allowed
- Property
- 88 rooms
06 — Questions
Frequently asked
What are the check-in and check-out times?
Check-in runs from 15:00 to 23:59, and check-out is from 07:00 to 11:00.
Is parking available at the hotel?
Yes, on-site parking is available, and there is also an electric vehicle charging station. Rates are not specified in the information provided.
Are pets allowed?
No, pets are not permitted at Twentyone Hotel.
The bottom line
Twentyone Hotel delivers a clean, modern stay in a location that guests consistently rate among the best in Rome. The staff are a real asset, and the price is fair for the offering. Be aware that some rooms are compact and breakfast is an added expense – but for a practical base near the Vatican, it's a solid choice.
8.4A reliable base near the Vatican with friendly service.
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